Patched 1/PTCH Products
Patched homolog 1 (PTC1) is a 170 - 175 kDa member of the Patched family of proteins. It is found on multiple cells types and forms a constitutive, inactivating complex with Smoothened. Upon SHH binding to PTC1, Smoothened is released and initiates downstream signaling.
Mouse PTC1 is a 12 transmembrane, 1434 aa glycoprotein that contains two terminal cytoplasmic domains. Only one mRNA species for PTC1 has been reported in mice. However, two or more splice forms exist, with variation occurring over the first 150 aa of the N-terminus. Over aa 108 - 422, mouse PTC1 shares 97% and 99% aa sequence identity with human and rat PTC1, respectively.
94 results for "Patched 1/PTCH" in Products
94 results for "Patched 1/PTCH" in Products
Patched 1/PTCH Products
Patched homolog 1 (PTC1) is a 170 - 175 kDa member of the Patched family of proteins. It is found on multiple cells types and forms a constitutive, inactivating complex with Smoothened. Upon SHH binding to PTC1, Smoothened is released and initiates downstream signaling.
Mouse PTC1 is a 12 transmembrane, 1434 aa glycoprotein that contains two terminal cytoplasmic domains. Only one mRNA species for PTC1 has been reported in mice. However, two or more splice forms exist, with variation occurring over the first 150 aa of the N-terminus. Over aa 108 - 422, mouse PTC1 shares 97% and 99% aa sequence identity with human and rat PTC1, respectively.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #OTI5C7 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: Patched 1/PTCH AntibodyBSA Free [NBP1-71662]](https://resources.bio-techne.com/images/products/Patched-1-PTCH-Antibody-Western-Blot-NBP1-71662-img0006.jpg "Western Blot: Patched 1/PTCH AntibodyBSA Free [NBP1-71662]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #OTI5C7 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: Patched 1/PTCH Antibody (OTI5C7) [NBP1-47945]](https://resources.bio-techne.com/images/products/Patched-1-PTCH-Antibody-5c7-Western-Blot-NBP1-47945-img0023.jpg "Western Blot: Patched 1/PTCH Antibody (OTI5C7) [NBP1-47945]")
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, ELISA, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: Patched 1/PTCH Antibody [NB100-2451]](https://resources.bio-techne.com/images/products/Patched-1-PTCH-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2451-img0002.jpg "Immunocytochemistry/ Immunofluorescence: Patched 1/PTCH Antibody [NB100-2451]")
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: Patched 1/PTCH Antibody [NB100-41101]](https://resources.bio-techne.com/images/products/Patched-1-PTCH-Antibody-Western-Blot-NB100-41101-img0001.jpg "Western Blot: Patched 1/PTCH Antibody [NB100-41101]")
| Reactivity: | Human, Mink |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Patched 1/PTCH Antibody [NBP2-19705]](https://resources.bio-techne.com/images/products/Patched-1-PTCH-Antibody-Western-Blot-NBP2-19705-img0002.jpg "Western Blot: Patched 1/PTCH Antibody [NBP2-19705]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI1H10 |
| Applications: | WB |
![Western Blot: Patched 1/PTCH Antibody (OTI1H10) [NBP2-45439]](https://resources.bio-techne.com/images/products/Patched-1-PTCH-Antibody-1H10-Western-Blot-NBP2-45439-img0001.jpg "Western Blot: Patched 1/PTCH Antibody (OTI1H10) [NBP2-45439]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #PSH03-53 |
| Applications: | WB |
| Applications: | WB, ELISA, MA, AP |
| Applications: | WB |
![Western Blot: Patched 1/PTCH Overexpression Lysate [NBL1-14924]](https://resources.bio-techne.com/images/products/Patched-1-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-14924-img0002.jpg "Western Blot: Patched 1/PTCH Overexpression Lysate [NBL1-14924]")
| Applications: | AC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI1H10 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI1H10 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #OTI5C7 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human, Mouse |
| Details: | Rat IgG2a Monoclonal Clone #413220 |
| Applications: | WB, IHC |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #413218 |
| Applications: | IHC, ICC |
Inhibitor of Hedgehog (Hh) signaling
| Chemical Name: | (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol |
| Purity: | ≥97% (HPLC) |
Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein
| Alternate Names: | HPI-4 |
| Chemical Name: | 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile |
| Purity: | ≥98% (HPLC) |
