TIMP-4 Products
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
80 results for "TIMP-4" in Products
80 results for "TIMP-4" in Products
TIMP-4 Products
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
| Sensitivity: | 10 pg/mL |
| Applications: | ELISA |
| Assay Range: | 78.1 - 5,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Human Milk) |
| Source: | Sf 21 (baculovirus) |
| Accession #: | Q99727 |
| Applications: | InhibAct |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #153934 |
| Applications: | WB, IHC |
| Assay Range: | 31.2 - 2,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA |
| Source: | NS0 |
| Accession #: | Q9JHB3 |
| Applications: | EnzAct |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #9:4-7 |
| Applications: | IHC, WB, ELISA |
![Immunohistochemistry: TIMP-4 Antibody (9:4-7) [NBP2-21658]](https://resources.bio-techne.com/images/products/TIMP-4-Antibody-9-4-7-Immunohistochemistry-NBP2-21658-img0004.jpg "Immunohistochemistry: TIMP-4 Antibody (9:4-7) [NBP2-21658]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #SB30c |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: TIMP-4 Antibody (SB30c)Azide and BSA Free [NBP1-28619]](https://resources.bio-techne.com/images/products/TIMP-4-Antibody-SB30c-Western-Blot-NBP1-28619-img0005.jpg "Western Blot: TIMP-4 Antibody (SB30c)Azide and BSA Free [NBP1-28619]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: TIMP-4 Antibody [NBP2-20645]](https://resources.bio-techne.com/images/products/TIMP-4-Antibody-Western-Blot-NBP2-20645-img0004.jpg "Western Blot: TIMP-4 Antibody [NBP2-20645]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
![Immunohistochemistry: TIMP-4 Antibody (MM0037-9F3) - Azide and BSA Free [NB110-61003]](https://resources.bio-techne.com/images/products/TIMP-4-Antibody-MM0037-9F3-Immunohistochemistry-NB110-61003-img0001.jpg "Immunohistochemistry: TIMP-4 Antibody (MM0037-9F3) - Azide and BSA Free [NB110-61003]")
| Applications: | ELISA |
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #SB30c |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #SB30c |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #9:4-7 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #9:4-7 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #SB30c |
| Applications: | IHC, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #9:4-7 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #9:4-7 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #9:4-7 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #9:4-7 |
| Applications: | IHC, WB, ELISA |