UNC5H2/UNC5B: Proteins and Enzymes
UNC5H2/UNC5B is a transmembrane molecule that mediates axon repulsion and growth cone collapse through interactions with Netrin, Neogenin, and FLRT3. Its association with DCC switches the DCC-Netrin-1 response from attraction to repulsion.
Outside the nervous system, UNC5H2 facilitates Netrin-1-mediated inhibition of capillary branching and leukocyte migration as well as Netrin-1-mediated promotion of osteoclast differentiation. It is downregulated in multiple cancers and inhibits tumor cell growth and invasion. It also plays a critical role in the development of atherosclerosis and the survival of renal tubular epithelial cells during acute kidney injury.
Products:
3 results for "UNC5H2/UNC5B Proteins and Enzymes" in Products
3 results for "UNC5H2/UNC5B Proteins and Enzymes" in Products
UNC5H2/UNC5B: Proteins and Enzymes
UNC5H2/UNC5B is a transmembrane molecule that mediates axon repulsion and growth cone collapse through interactions with Netrin, Neogenin, and FLRT3. Its association with DCC switches the DCC-Netrin-1 response from attraction to repulsion.
Outside the nervous system, UNC5H2 facilitates Netrin-1-mediated inhibition of capillary branching and leukocyte migration as well as Netrin-1-mediated promotion of osteoclast differentiation. It is downregulated in multiple cancers and inhibits tumor cell growth and invasion. It also plays a critical role in the development of atherosclerosis and the survival of renal tubular epithelial cells during acute kidney injury.
Products:
| Source: | NS0 |
| Accession #: | O08722 |
| Applications: | Bind |
| Applications: | AC |
| Source: | CHO |
| Accession #: | Q8IZJ1 |
| Applications: | BA |