IGF-II R/IGF2R Antibody (MEM-238) [mFluor Violet 610 SE]

Novus Biologicals, part of Bio-Techne | Catalog # NB500-464MFV610

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NB500-464MFV610
Print Quote
Bulk Order
Forumulation
Catalog #
BSA Free
NB500-464
View Product
100% Guarantee

Key Product Details

Species Reactivity

Validated:

Human, Primate

Applications

CyTOF-ready, Flow Cytometry, Immunoprecipitation, Western Blot

Label

mFluor Violet 610 SE (Excitation = 421 nm, Emission = 613 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # MEM-238

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all IGF-II R/IGF2R Antibodies »

Product Summary for IGF-II R/IGF2R Antibody (MEM-238) [mFluor Violet 610 SE]

Immunogen

Recombinant Vaccinia virus encoding CD222.

Epitope

Recognizes an epitope between domains 2 and 5.

Specificity

The antibody MEM-238 recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal ompartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.

Marker

Late Endosome Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for IGF-II R/IGF2R Antibody (MEM-238) [mFluor Violet 610 SE]

IGF-II R/IGF2R Antibody (MEM-238) [mFluor Violet 610 SE]

IGF-II R/IGF2R Antibody (MEM-238) [mFluor Violet 610 SE] [NB500-464MFV610] -

IGF-II R/IGF2R Antibody (MEM-238) [mFluor Violet 610 SE] [NB500-464MFV610] - Vial of mFluor Violet 610 conjugated antibody. mFluor Violet 610 is optimally excited at 421 nm by the Violet laser (405 nm) and has an emission maximum of 613 nm.

Applications for IGF-II R/IGF2R Antibody (MEM-238) [mFluor Violet 610 SE]

Application
Recommended Usage

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: IGF-II R/IGF2R

CD222 is a 250kDa transmembrane protein with a short cytoplasmic tail containing an internalization signal. CD222 was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via CD222 either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of CD222 molecules (approximately 90-95%) are located intracellularly, only 5-10% is present on the cell membrane. The internalization rate seems to be enhanced by ligand induced dimerization of CD222 as well as by phosphorylation of its cytoplasmic serine. CD222 is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta [PROW].

Long Name

Insulin-like Growth Factor II Receptor

Alternate Names

CD222, CIMPR, IGF-IIR, IGF2R, IGFIIR, M6P-R, MPRI

Gene Symbol

IGF2R

Additional IGF-II R/IGF2R Products

Product Documents for IGF-II R/IGF2R Antibody (MEM-238) [mFluor Violet 610 SE]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for IGF-II R/IGF2R Antibody (MEM-238) [mFluor Violet 610 SE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.