At Bio-Techne, we are committed to empowering neuroscience research and discovery by providing the highest quality materials, reagents, assay solutions, instruments and technical support. From optimized cell culture media and supplements to automated analysis platforms that can accelerate discoveries and streamline your workflow, we have the solutions to meet your specific research needs.
Neuroscience Areas of Focus
Spatial Mapping and Phenotyping
Spatial biology has opened the door to exciting new possibilities in neuroscience research. Our solutions allow interrogation of target genes and proteins you want, in the combinations you need, to achieve your research goals.
Featured Solutions
High Resolution Spatial Mapping
Detect target RNAs with sub-cellular resolution using RNAscope™ assays. Our established spatial technology has been cited in over 8,000 publications with 1000s of predesigned neuro probes in catalog. Multiplexing and multiomic capabilities enable detection of unique splice variants, mRNAs, miRNAs, circRNAs and proteins in spatial context.
Antibodies
To support you in your spatial biology research, we provide a comprehensive suite of high-quality antibodies for spatial biology. Unlock convenient multiplex panel development for spatial applications with conjugation-ready antibodies provided in BSA and Azide-free formats.
Discover Antibodies for Spatial Biology
Dual Assay Capabilities
Combine the power of RNAscope ISH and IHC with our RNA-Protein Co-Detection Assays - leverage the best of RNA and protein detection to provide unique insights into neuronal and glial cell interactions in the nervous system.
View RNA-Protein Co-Detection Assays
TSA Vivid™ Fluorophore Kits
Designed to support our RNAscope Multiplex Fluorescent V2 assay, our TSA Vivid dyes offer improved signal-to-noise, are brighter than equivalent competitor fluorophores and are suitable for multiplexing.
Enhanced Sensitivity
Providing augmented sensitivity, our BaseScope™ ISH assay can detect exon junctions, splice variants, short/highly homologous RNA sequences and point mutations to help interrogate the complex brain transcriptome.
Learn More About BaseScope™ ISH
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Neural Cell Imaging and Detection
Live and Fixed Cell Imaging
The nervous system is astonishingly complex, displaying a high degree of cell-type heterogeneity and delicate organizational and spatial construction. This presents unique challenges when it comes to imaging and detection, and sometimes requires probing of gene and protein expression profiles. We’ve got you covered with a suite of tools for visualizing cellular morphology, target antigens or RNA expression in live cells, fixed cells or tissue.
Featured Solutions
Detect Key Disease Targets
Detect, localize and quantify important neurological disease proteins with our extensive portfolio of Immunohistochemistry (IHC) products. We offer a comprehensive suite of high-quality validated primary and secondary antibodies for disease research areas such as Alzheimer’s Disease, Parkinson’s Disease, Glioblastoma and more, plus detection reagents and probes for a number of highly sought after neuroscience targets.
Visualize Complex Structures
We offer a broad range of fluorescent dyes and probes optimized for neuroscience imaging, to enable easy detection and imaging of your target of interest within complex nervous tissues. Whether your target is an ion, a membrane protein or neuron, we have the dyes, probes and reagents to meet your highly specific neuroscience imaging needs.
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View Our Newly Expanded Ion Indicator Range
Automated Protein Detection
Accelerate your protein detection with our Simple Western™ platform – an innovative benchtop instrument that automates the entire Western blot workflow. Simple Western provides quantitative protein analysis by size and charge and ensures you get the most from your precious cell and tissue lysate samples.
Learn More About Simple Western™
Neural Cell Isolation
Boost reproducibility in your cell-based assays and isolate neural cells for imaging with the Pala Single Cell Dispenser. Pala is a compact, easy-to-use, maintenance-free benchtop instrument that provides effortless single cell isolation through flow cytometry and microfluidics technology.
Discover the Pala Single Cell Dispenser
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Biomarker Quantitation and Validation
Sensitive Detection of Neuro Biomarkers
Biomarker measurements in non-invasive sample types are becoming increasingly preferred in the characterization of neurological diseases and can be highly valuable for disease diagnosis, prognosis, and staging. Explore our comprehensive range of tools that provide the accuracy, reproducibility and sensitivity you need for successful biomarker discovery and validation.
Featured Solutions
Ultrasensitive Biomarker Quantification in Serum
Ella™ is our pioneering automated ELISA platform that enables ultrasensitive quantitation of neurobiomarkers in serum, including beta amyloid 40/42, GFAP, NF-L and NF-H with unrivaled precision and reproducibility. These Simple Plex™ cartridges are validated, ready-to-use assays powered by R&D Systems for unmatched simple workflow and performance.
Neuroinflammatory Protein Biomarker Detection
Measure neurological and immune biomarkers with specific R&D Systems ELISA kits and multiplexing Luminex assay solutions – we provide a host of assays and multiplex panels for the detection of beta amyloid and tau protein as well as neuroinflammatory biomarkers.
Discover Our ELISA Kits
Learn About Our Luminex Assays
Protein Detection Made Easy
Accelerate your protein detection with our Simple Western™ platform – an innovative benchtop instrument that automates the entire Western blot workflow. Simple Western provides quantitative protein analysis by size and charge and ensures you get the most from your precious cell and tissue lysate samples.
Learn More About Simple Western™
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Modulate Neural Activity
Investigate, Manipulate and Control Neural Cell Functioning
Revealing the precise mechanisms that govern nervous system function requires a comprehensive molecular toolkit to manipulate receptors, neurotransmitters, transporters, ion channels and other signaling proteins. Whether you’re looking to control neuronal function in vitro or in vivo, we have you covered with a vast array of high-quality ligands, small molecules and additional tools.
Featured Solutions
Explore Molecular Neuroscience
We offer a comprehensive range of high-performance neuroscience reagents to meet your research needs. Our portfolio includes neurotransmitter receptor agonists and antagonists, ion channel modulators and much more. Each is manufactured to the highest quality assurance standards so you can move your research forward with confidence.
Find GPCR Antibodies
View Agonists and Inhibitors
Uncover Neuronal Signaling
Electrophysiology is a vital tool for neuroscience research, but you need the right tools to robustly interrogate neuronal signaling activity. That’s why we provide a comprehensive suite of electrophysiology reagents including high-quality caged compounds, ion indicators and DREADD ligands to help you control excitatory cell activity.
Find Your Electrophysiology Reagents
View Our Newly Expanded Ion Indicator Range
Neural Cell Culture
Differentiate, Grow and Monitor Neural Stem Cells
Neural cells are highly sensitive and require specific environmental conditions to survive. Even slight changes in temperature, pH, nutrient and oxygen levels can affect their viability while maintaining the desired level of differentiation can also be challenging. To meet the specific need of neural cells, we provide a range of optimized neural cell culture media and supplements so you can be assured that your cells perform optimally in experiments.
Featured Solutions
Optimize Culture Conditions
We offer a comprehensive portfolio of high-quality culture media and supplements for improved growth, survival and differentiation of cultured neural cells. This includes animal-free and xeno-free media, optimized media and supplements for neural stem cells, recombinant neurotrophic factors and kits that package all necessary reagents required for neuronal cell culture.
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Culture Consistent Neural Organoids
Looking to culture 3D neural organoids? We’ve got you covered with a full solution for neural organoid culture, including Cultrex™ extracellular matrices, growth factors, small molecules, media and media supplements. Designed to promote robust growth while maintaining consistent, reproducible culture conditions, our solutions have been carefully designed and optimized for 3D applications. Also available, are tissue clearing kits that unlock novel organoid analysis and imaging opportunities.
Discover Cultrex™ Extracellular Matrices
View Our Tissue Clearing Kits
Single Cell Dispensing
Need to seed single cells into plates for analysis? Our Namocell™ benchtop single-cell dispensers harness microfluidic technology to gently and efficiently sort cells. Fitting into a laminar flow hood for convenience, these powerful instruments can dispense single cells into a 96-well plate in 1 minute.
Diagnostics
End-to-End Companion Diagnostics Services
Bio-Techne has partnered with pharma companies to provide precision medicine solutions across a wide range of disease areas, including neurodegenerative diseases. Bio-Techne’s in-house technologies and expertise accelerate the journey from Clinical Trial Assay (CTA) to Companion Diagnostics (CDx) offering customizable delivering solutions through validated assay development, robust protein analysis, multi-omics capabilities, regulatory support and more.
Partner With Us, Accelerate Your CDx Journey
Empower Biomarker Discovery for Neurological Diseases
The exosome approach to biomarker discovery and development has distinct advantages over other liquid biopsy methods like ctDNA and CTCs. The ExosomeDx™ Exosome Platform analyzes exosomal RNA, protein and cfDNA to find clinical utility in diverse disease areas, including neurodegenerative disorders.
Discover the ExosomeDx™ Exosome Platform
Discover Neurogenetics Solutions
Asuragen, a Bio-Techne brand, stands to accelerate the journey from research to laboratory molecular assays by reliably amplifying GC-rich and repetitive DNA regions that have traditionally been challenging to detect. With a common workflow and expertise in reliably amplifying GC-rich and repetitive DNA regions, the AmplideX® PCR/CE FMR1 (RUO, CE-IVD), C9orf72(RUO), HTT(RUO), and DMPK(RUO) assays offer researchers a streamlined solution to detect key biomarkers in neurodegenerative disease in a ready-to-use kit.
Explore Kitted Solutions
Complex Molecular Genetic Testing Made Simple
