CTLA-4 Products
CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
5 results for "CTLA-4" in Products
5 results for "CTLA-4" in Products
CTLA-4 Products
CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
| Source: | CHO |
| Accession #: | P16410 |
| Applications: | BA |
| Source: | Sf 21 (baculovirus) |
| Accession #: | Q6GR94 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q6GTR6 |
| Applications: | BA |
| Applications: | ELISA |
![ELISA: Human CTLA-4 ELISA Kit (Colorimetric) [NBP1-91268]](https://resources.bio-techne.com/images/products/CTLA-4-ELISA-Kit-ELISA-NBP1-91268-img0001.jpg "ELISA: Human CTLA-4 ELISA Kit (Colorimetric) [NBP1-91268]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #rCTLA4/7219 |
| Applications: | IHC |
![CTLA-4 Antibody (rCTLA4/7219) [Alexa Fluor® 647]](https://resources.bio-techne.com/images/products/nbp3-20809af647_mouse-ctla-4-mab-rctla4-7219-alexa-fluor-647-immunohistochemistry-paraffin-112202316312..jpg "Immunohistochemistry-Paraffin: Mouse CTLA-4 mAb (rCTLA4/7219) [Alexa Fluor® 647] [NBP3-20809AF647] -")