FGFR3 Products
FGFR3 (fibroblast growth factor receptor 3), also known as CEK2 and CD333, is a transmembrane receptor tyrosine kinase that plays a role in skeletal development and tumorigenesis. Alternative splicing generates beta isoforms of the receptor which lack the first Ig-like domain as well as IIIb isoforms that have a substitution in the third Ig-like domain.
FGFR3 (IIIb) triggers cell proliferation in response to FGF acidic and FGF-9 while FGFR3 (IIIc) shows a wider selectivity that includes FGF acidic, FGF basic/FGF2, FGF-4, -8, -9, -17, -18, -19, and -20. FGF-mediated activation of FGFR3 is dependent on the presence of heparan sulfate proteoglycans. FGFR3 functions as a negative regulator of endochondral bone growth, and FGFR3 mutations are associated with chondrodysplasia in humans. The development of many cancers is associated with mutations or dysregulation of FGFR3.
Products:
230 results for "FGFR3" in Products
230 results for "FGFR3" in Products
FGFR3 Products
FGFR3 (fibroblast growth factor receptor 3), also known as CEK2 and CD333, is a transmembrane receptor tyrosine kinase that plays a role in skeletal development and tumorigenesis. Alternative splicing generates beta isoforms of the receptor which lack the first Ig-like domain as well as IIIb isoforms that have a substitution in the third Ig-like domain.
FGFR3 (IIIb) triggers cell proliferation in response to FGF acidic and FGF-9 while FGFR3 (IIIc) shows a wider selectivity that includes FGF acidic, FGF basic/FGF2, FGF-4, -8, -9, -17, -18, -19, and -20. FGF-mediated activation of FGFR3 is dependent on the presence of heparan sulfate proteoglycans. FGFR3 functions as a negative regulator of endochondral bone growth, and FGFR3 mutations are associated with chondrodysplasia in humans. The development of many cancers is associated with mutations or dysregulation of FGFR3.
Products:
Clone 136312 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136312 |
| Applications: | WB, Flow, IHC, ICC |
Clone 136334 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136334 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI1B10 |
| Applications: | IHC, WB, ICC/IF, KO |
![Western Blot: FGFR3 Antibody (OTI1B10) [NBP2-45716]](https://resources.bio-techne.com/images/products/FGFR3-Antibody-OTI1B10-Western-Blot-NBP2-45716-img0003.jpg "Western Blot: FGFR3 Antibody (OTI1B10) [NBP2-45716]")
Biotinylated
| Source: | HEK293 |
| Accession #: | NP_001156685.1 |
| Applications: | BA |
Clone 136334 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136334 |
| Applications: | Flow |
| Source: | NS0 |
| Accession #: | P22607 |
| Applications: | BA |
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #JM110-33 |
| Applications: | IHC, WB, ICC/IF, Flow |
![Western Blot: FGFR3 Antibody (JM110-33) [NBP2-66840]](https://resources.bio-techne.com/images/products/FGFR3-Antibody-JM110-33-Western-Blot-NBP2-66840-img0010.jpg "Western Blot: FGFR3 Antibody (JM110-33) [NBP2-66840]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #2H10B4 |
| Applications: | IHC, WB, ELISA, Flow, CyTOF-ready |
![Western Blot: FGFR3 Antibody (2H10B4)BSA Free [NBP2-52468]](https://resources.bio-techne.com/images/products/FGF-R3-Antibody-2H10B4-Western-Blot-NBP2-52468-img0010.jpg "Western Blot: FGFR3 Antibody (2H10B4)BSA Free [NBP2-52468]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136318 |
| Applications: | WB, Neut |
| Source: | NS0 |
| Accession #: | Q61851 |
| Applications: | BA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: FGFR3 AntibodyBSA Free [NBP2-41227]](https://resources.bio-techne.com/images/products/FGFR3-Antibody-Western-Blot-NBP2-41227-img0001.jpg "Western Blot: FGFR3 AntibodyBSA Free [NBP2-41227]")
Clone 136334 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136334 |
| Applications: | Flow |
Biotinylated
| Source: | HEK293 |
| Accession #: | NP_001156685.1 |
| Applications: | BA |
| Assay Range: | 250 - 16,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #136812 |
| Applications: | Neut |
Clone 136334 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136334 |
| Applications: | Flow |
Clone 136334 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136334 |
| Applications: | Flow |
Biotinylated Fc Chimera
| Source: | HEK293 |
| Accession #: | P22607.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_001156689 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_001156685 |
| Applications: | BA |
Clone 136334 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136334 |
| Applications: | Flow |
Clone 136334 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136334 |
| Applications: | Flow |
Clone 136334 was used by HLDA to establish CD designation
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136334 |
| Applications: | Flow |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #136315 |
| Applications: | Neut |
