GSK-3 alpha/beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
24 results for "GSK-3 alpha/beta" in Products
24 results for "GSK-3 alpha/beta" in Products
GSK-3 alpha/beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
Highly selective GSK-3 inhibitor; acts as Wnt activator
| Alternate Names: | CHIR99021,CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, CyTOF-ready, ICC, ICFlow |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SY26-05 |
| Applications: | IHC, WB, ICC/IF, IP |
| Assay Range: | 156 - 10,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human, Mouse, Rat, Canine, Bovine, +5 More |
| Details: | Mouse IgG2B Monoclonal Clone #1H8 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 alpha/beta Antibody (1H8) [NB110-85523]](https://resources.bio-techne.com/images/products/GSK-3-alpha-beta-Antibody-1H8-Western-Blot-NB110-85523-img0003.jpg "Western Blot: GSK-3 alpha/beta Antibody (1H8) [NB110-85523]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, IP |
![Western Blot: GSK-3 alpha/beta [p Ser21] AntibodyAzide and BSA Free [NBP3-05443]](https://resources.bio-techne.com/images/products/GSK-3-alpha-beta-[p-Ser21]-Antibody-Western-Blot-NBP3-05443-img0003.jpg "Western Blot: GSK-3 alpha/beta [p Ser21] AntibodyAzide and BSA Free [NBP3-05443]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #S08-8G7 |
| Applications: | WB |
![Western Blot: GSK-3 alpha/beta Antibody (S08-8G7) [NBP3-19938]](https://resources.bio-techne.com/images/products/GSK-3-alpha-beta-Antibody-S08-8G7-Western-Blot-NBP3-19938-img0001.jpg "Western Blot: GSK-3 alpha/beta Antibody (S08-8G7) [NBP3-19938]")
| Reactivity: | Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: GSK-3 alpha/beta [p Ser9] Antibody [NB300-741]](https://resources.bio-techne.com/images/products/GSK3-alpha-beta-[p-Ser9]-Antibody-Western-Blot-NB300-741-img0001.jpg "Western Blot: GSK-3 alpha/beta [p Ser9] Antibody [NB300-741]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR1908 |
| Applications: | IHC, WB, ICC/IF, IP |
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #L5 |
| Applications: | WB, IP |
![Western Blot: GSK-3 alpha/beta Antibody (L5) [NBP2-29873]](https://resources.bio-techne.com/images/products/GSK3-alpha-beta-Antibody-Western-Blot-NBP2-29873-img0001.jpg "Western Blot: GSK-3 alpha/beta Antibody (L5) [NBP2-29873]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #M132 |
| Applications: | WB |
![GSK-3 alpha/beta [p Tyr216] Antibody (M132)](https://resources.bio-techne.com/images/products/nbp3-23367_mouse-gsk-3-alpha-beta-p-tyr216-mab-m132-19920231856920.jpg "Western Blot: GSK-3 alpha/beta [p Tyr216] Antibody (M132) [NBP3-23367] -")
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
GSK-3β inhibitor; also inhibits cdks
| Chemical Name: | 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one |
| Purity: | ≥98% (HPLC) |
Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥97% (HPLC) |
Potent, selective GSK-3 inhibitor
| Chemical Name: | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% (HPLC) |
Potent GSK-3 inhibitor; also inhibits cdks
| Alternate Names: | 6BIO |
| Chemical Name: | (2'Z,3'E)-6-Bromoindirubin-3'-oxime |
| Purity: | ≥98% (HPLC) |
Potent, selective GSK-3 inhibitor
| Chemical Name: | 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Purity: | ≥99% (HPLC) |
Selective GSK-3 inhibitor
| Chemical Name: | N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea |
| Purity: | ≥99% (HPLC) |
Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
| Alternate Names: | NIBR3049 |
| Chemical Name: | 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% (HPLC) |
Selective non-ATP competitive inhibitor of GSK 3β
| Alternate Names: | NP 01139 |
| Chemical Name: | 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione |
| Purity: | ≥98% (HPLC) |
Highly potent, selective GSK-3 inhibitor
| Chemical Name: | 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea |
| Purity: | ≥99% (HPLC) |
Potent GSK-3β inhibitor
| Chemical Name: | 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole |
| Purity: | ≥99% (HPLC) |
