IL-1 beta/IL-1F2 Products
IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.
367 results for "IL-1 beta/IL-1F2" in Products
367 results for "IL-1 beta/IL-1F2" in Products
IL-1 beta/IL-1F2 Products
IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.
| Sensitivity: | 0.063 pg/mL |
| Applications: | ELISA |
| Assay Range: | 0.125 - 8 pg/mL (Serum, EDTA Plasma, Heparin Plasma, Saliva) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #8516 |
| Applications: | WB, Simple Western, CyTOF-ready, ICC, ICFlow, +1 More |
| Assay Range: | 62.5 - 4,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #2805 |
| Applications: | WB, Simple Western, ICC, Neut |
| Reactivity: | Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC, Neut |
| Source: | E. coli |
| Accession #: | Q63264 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Rat IgG1 Monoclonal Clone #30311 |
| Applications: | Neut |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, Neut |
