LAP (TGF-beta 1) Products
TGF-beta 1 is expressed as a proprotein. It is cleaved within the trans-Golgi to yield a latency-associated peptide (LAP) and the mature TGF-beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain noncovalently associated after secretion, forming the small latent TGF-beta 1 complex. Purified LAP can also associate with active TGF-beta and neutralize TGF-beta activity.
Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that can interact with the extracellular matrix. TGF-beta activation from latency is controlled by multiple factors including Plasmin, MMP-9, Thrombospondin-1, and various Integrins. The TGF-beta 1 LAP is capable of complexing with and inactivating all other human TGF-beta isoforms and those of most other species.
Products:
143 results for "LAP (TGF-beta 1)" in Products
143 results for "LAP (TGF-beta 1)" in Products
LAP (TGF-beta 1) Products
TGF-beta 1 is expressed as a proprotein. It is cleaved within the trans-Golgi to yield a latency-associated peptide (LAP) and the mature TGF-beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain noncovalently associated after secretion, forming the small latent TGF-beta 1 complex. Purified LAP can also associate with active TGF-beta and neutralize TGF-beta activity.
Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that can interact with the extracellular matrix. TGF-beta activation from latency is controlled by multiple factors including Plasmin, MMP-9, Thrombospondin-1, and various Integrins. The TGF-beta 1 LAP is capable of complexing with and inactivating all other human TGF-beta isoforms and those of most other species.
Products:
For use with catalog number DLAP00
| Applications: | ELISA, Ctrl |
| Source: | Sf 21 (baculovirus) |
| Accession #: | P01137.2 |
| Applications: | BA |
| Sensitivity: | 3.4 pg/mL |
| Applications: | ELISA |
| Assay Range: | 23.4 - 1,500 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma, Urine) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, ICC, Neut |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #7F6 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow |
![Western Blot: LAP (TGF-beta 1) Antibody (7F6)BSA Free [NBP2-22114]](https://resources.bio-techne.com/images/products/TGF-beta-1-Antibody-7F6-Western-Blot-NBP2-22114-img0002.jpg "Western Blot: LAP (TGF-beta 1) Antibody (7F6)BSA Free [NBP2-22114]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, ICC, Neut |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #27235 |
| Applications: | ICC, Neut |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #860206 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Rat IgG2A Monoclonal Clone #860206 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #27232 |
| Applications: | Flow |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #7F6 |
| Applications: | IHC, WB, ELISA, Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #27232 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #27240 |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #27232 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #860206 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #860206 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1015016 |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #27232 |
| Applications: | Flow, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1015022 |
| Applications: | ELISA, CyTOF-ready, ICC, ICFlow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #860206 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #27232 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1015022 |
| Applications: | ICFlow |
| Assay Range: | 62.5 - 4,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #9005 |