LDLR Products
LDLR (Low Density Lipoprotein Receptor) is a widely expressed cell surface scavenger receptor. LDLR binds ApoB and ApoE, the apolipoproteins of low- and very low-density lipoproteins (LDL and VLDL), respectively. Hepatocyte LDLR is responsible for endocytosis and clearing of most plasma LDL cholesterol. At the low pH of the endocytic vesicle, it dissociates, allowing degradation of LDL and recycling of LDLR to the cell surface. Lack of LDLR expression or function causes familial hypercholesterolemia (FH). The protease PCSK9 can also cause increased plasma cholesterol by promoting LDLR degradation rather than recycling to the cell surface.
Products:
276 results for "LDLR" in Products
276 results for "LDLR" in Products
LDLR Products
LDLR (Low Density Lipoprotein Receptor) is a widely expressed cell surface scavenger receptor. LDLR binds ApoB and ApoE, the apolipoproteins of low- and very low-density lipoproteins (LDL and VLDL), respectively. Hepatocyte LDLR is responsible for endocytosis and clearing of most plasma LDL cholesterol. At the low pH of the endocytic vesicle, it dissociates, allowing degradation of LDL and recycling of LDLR to the cell surface. Lack of LDLR expression or function causes familial hypercholesterolemia (FH). The protease PCSK9 can also cause increased plasma cholesterol by promoting LDLR degradation rather than recycling to the cell surface.
Products:
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, Block, ICC |
| Sensitivity: | 0.064 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.313 - 20 ng/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma) |
| Source: | NS0 |
| Accession #: | Q59FQ1 |
| Applications: | Bind |
| Sensitivity: | 10.3 pg/mL |
| Applications: | ELISA |
| Assay Range: | 62.5 - 4,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, Heparin Plasma, Urine) |
| Reactivity: | Human, Mouse, Rat, Bovine, Porcine |
| Details: | Mouse IgG2B Monoclonal Clone #C7 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +3 More |
![Western Blot: LDLR Antibody (C7) [NBP1-78159]](https://resources.bio-techne.com/images/products/LDL-R-Antibody-C7-Western-Blot-NBP1-78159-img0008.jpg "Western Blot: LDLR Antibody (C7) [NBP1-78159]")
| Source: | NS0 |
| Accession #: | P01130 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #472413 |
| Applications: | Flow |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Func, Simple Western, +1 More |
![Knockout Validated: LDLR Antibody - BSA Free [NBP1-06709]](https://resources.bio-techne.com/images/products/LDLR-Antibody-Knockout-Validated-NBP1-06709-img0009.jpg "Western Blot: LDLR Antibody - BSA Free [NBP1-06709]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #472413 |
| Applications: | WB, Flow, IP, CyTOF-ready |
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #SJ0197 |
| Applications: | IHC, WB, ICC/IF, Flow |
![Western Blot: LDLR Antibody (SJ0197) [NBP2-67414]](https://resources.bio-techne.com/images/products/LDLR-Antibody-SJ0197-Western-Blot-NBP2-67414-img0008.jpg "Western Blot: LDLR Antibody (SJ0197) [NBP2-67414]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #472413 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #263123 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #472413 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1B10H10 |
| Applications: | IHC, WB, ELISA, Flow, CyTOF-ready |
![Western Blot: LDLR Antibody (1B10H10)BSA Free [NBP2-52502]](https://resources.bio-techne.com/images/products/LDL-R-Antibody-1B10H10-Western-Blot-NBP2-52502-img0003.jpg "Western Blot: LDLR Antibody (1B10H10)BSA Free [NBP2-52502]")
| Source: | HEK293 |
| Accession #: | XP_005588053.1 |
| Applications: | BA |
| Assay Range: | 0.625 - 40 ng/mL |
| Applications: | ELISA |
| Assay Range: | 125 - 8,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #472413 |
| Applications: | Flow |
| Assay Range: | 62.5 - 4,000 pg/mL |
| Applications: | ELISA |
Asp193Ala
| Source: | HEK293 |
| Accession #: | P01130 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #263123 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #263123 |
| Applications: | Flow |