SMAC/Diablo Products
SMAC (second mitochondria-derived activator of caspase)/Diablo, the mammalian functional homologue of Drosophila Hid, Grim, and Reaper, regulates apoptosis by neutralizing inhibitor of apoptosis (IAP) proteins. IAP family members contain one to three baculovirus IAP repeat (BIR) domains, each exhibiting distinct functions and caspase specificity. The BIR2 domain inhibits caspase-3 and –7, whereas the BIR3 domain inhibits caspase-9 activity. SMAC/Diablo interacts with BIR2 and BIR3 domains of IAPs, thereby neutralizing IAP inhibition and promoting caspase catalytic activity and apoptosis.
51 results for "SMAC/Diablo" in Products
51 results for "SMAC/Diablo" in Products
SMAC/Diablo Products
SMAC (second mitochondria-derived activator of caspase)/Diablo, the mammalian functional homologue of Drosophila Hid, Grim, and Reaper, regulates apoptosis by neutralizing inhibitor of apoptosis (IAP) proteins. IAP family members contain one to three baculovirus IAP repeat (BIR) domains, each exhibiting distinct functions and caspase specificity. The BIR2 domain inhibits caspase-3 and –7, whereas the BIR3 domain inhibits caspase-9 activity. SMAC/Diablo interacts with BIR2 and BIR3 domains of IAPs, thereby neutralizing IAP inhibition and promoting caspase catalytic activity and apoptosis.
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #78-1-118 |
| Applications: | WB, ICC/IF, IP |
![Western Blot: SMAC/Diablo Antibody (78-1-118) [NB500-213]](https://resources.bio-techne.com/images/products/Smac-Antibody-78-1-118-Western-Blot-NB500-213-img0002.jpg "Western Blot: SMAC/Diablo Antibody (78-1-118) [NB500-213]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: SMAC/Diablo Antibody [NB100-56311]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-Western-Blot-NB100-56311-img0006.jpg "Western Blot: SMAC/Diablo Antibody [NB100-56311]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP, Simple Western |
![Western Blot: SMAC/Diablo Antibody [NB100-56165]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-Western-Blot-NB100-56165-img0003.jpg "Western Blot: SMAC/Diablo Antibody [NB100-56165]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, Simple Western |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, IP |
![Western Blot: SMAC/Diablo AntibodyBSA Free [NBP1-76772]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-Western-Blot-NBP1-76772-img0006.jpg "Western Blot: SMAC/Diablo AntibodyBSA Free [NBP1-76772]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #S08-6A3 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: SMAC/Diablo Antibody (S08-6A3) [NBP3-19775]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-S08-6A3-Western-Blot-NBP3-19775-img0003.jpg "Western Blot: SMAC/Diablo Antibody (S08-6A3) [NBP3-19775]")
| Source: | E. coli |
| Accession #: | Q9NR28 |
| Applications: | InhibAct |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunohistochemistry-Paraffin: SMAC/Diablo Antibody [NBP1-84262]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-Immunohistochemistry-Paraffin-NBP1-84262-img0009.jpg "Immunohistochemistry-Paraffin: SMAC/Diablo Antibody [NBP1-84262]")
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #RM271 |
| Applications: | IHC, WB |
![Western Blot: SMAC/Diablo Antibody (RM271) [NBP2-61586]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-RM271-Western-Blot-NBP2-61586-img0003.jpg "Western Blot: SMAC/Diablo Antibody (RM271) [NBP2-61586]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #006 |
| Applications: | WB, ELISA, ICC/IF, Flow |
![Western Blot: SMAC/Diablo Antibody (006) [NBP2-89251]](https://resources.bio-techne.com/images/products/SMAC-Diablo-Antibody-006-Western-Blot-NBP2-89251-img0001.jpg "Western Blot: SMAC/Diablo Antibody (006) [NBP2-89251]")
| Applications: | ELISA |
| Applications: | AC |
![Western Blot: SMAC/Diablo Antibody Blocking Peptide [NBP1-76772PEP]](https://resources.bio-techne.com/images/products/Smac-Peptide-Western-Blot-NBP1-76772PEP-img0001.jpg "Western Blot: SMAC/Diablo Antibody Blocking Peptide [NBP1-76772PEP]")
| Applications: | AC |
| Applications: | WB |
![Western Blot: SMAC/Diablo Overexpression Lysate [NBP2-11272]](https://resources.bio-techne.com/images/products/Smac-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-11272-img0001.jpg "Western Blot: SMAC/Diablo Overexpression Lysate [NBP2-11272]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #006 |
| Applications: | WB, ELISA, ICC/IF, Flow |
| Applications: | ELISA |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #006 |
| Applications: | WB, ELISA, ICC/IF, Flow |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #006 |
| Applications: | WB, ELISA, ICC/IF, Flow |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #006 |
| Applications: | WB, ELISA, ICC/IF, Flow |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #006 |
| Applications: | WB, ELISA, ICC/IF, Flow |
Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
Contains 8 membranes - each spotted in duplicate with 21 different apoptosis antibodies
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #006 |
| Applications: | WB, ELISA, ICC/IF, Flow |