TIMP-4 Products
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
23 results for "TIMP-4" in Products
23 results for "TIMP-4" in Products
TIMP-4 Products
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #153934 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
![Immunohistochemistry: TIMP-4 Antibody (MM0037-9F3) - Azide and BSA Free [NB110-61003]](https://resources.bio-techne.com/images/products/TIMP-4-Antibody-MM0037-9F3-Immunohistochemistry-NB110-61003-img0001.jpg "Immunohistochemistry: TIMP-4 Antibody (MM0037-9F3) - Azide and BSA Free [NB110-61003]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #MM0037-9F3 |
| Applications: | IHC, WB |