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Why Visualize RNA and Protein Together?
Understanding the spatial relationship between RNA and protein is crucial for gaining a holistic view of cellular processes. However, analyzing these molecules separately, as has been done traditionally, misses the intricate interplay that defines tissue function and disease progression. Spatial Multiomics examines RNA and proteins in relation to tissue morphology enabling a complete understanding of gene expression regulation and protein function within specific cellular contexts.
Secreted Protein and its Origin
Secreted Protein and its Origin
RNAscope Multiplex V2 assay for studying Cytotoxic T lymphocytes in cervical cancer tissue. T cells were identified using protein marker CD3 while cytokine markers IFNG and CXCL9 were detected using RNA.
Characterize Immune Cells in the Tumor Microenvironment
Characterize Immune Cells in the Tumor Microenvironment
Visualizing TIL activation in Colon cancer. Using codetection to identify tumor infiltrating regulatory T cells marked by CD4+/FOXP3+ , Cytotoxic T lymphocytes seen as CD8+/ IFNG+.
Visualize Changes in Cell State
Visualize Changes in Cell State
Mapping tumor associated M1/M2 macrophages marked by CD163+ / CD68+ , IL1B+ / IL10+ in cervical cancer tissue
- Comprehensive Insights: Capture the full picture of cellular activities
- Enhanced Data Quality: Achieve high-resolution, colocalized detection
- Improved Research Outcomes: Uncover new therapeutic targets and disease outcomes
RNAscope™ Multiomic LS Assay
RNAscope™ Multiomic LS Assay
Proven class-leading single-molecule RNAscope technology is leveraged to enable simultaneous detection of up to 6 total proteins and RNA targets with single cell resolution automated on the automated assay for the Leica Biosystems BOND RX system.
RNAscope™ HiPlex Pro for COMET™
RNAscope™ HiPlex Pro for COMET™
Combining RNAscope HiPlex Pro with seqIF™ (sequential immunofluorescence) on COMET with a protease-free, fully automated workflow, same-section RNA and multiplex protein detection with the ability to select any 12 RNAscope targets, and up to 24 IF targets using off-the-shelf, non-conjugated primary antibodies.
Protease-free Sequential RNA-Protein Detection
Protease-free Sequential RNA-Protein Detection
Leverage the robustness of RNAscope technology by combining in situ hybridization and IHC protocol in the same sample slide leveraging the sequential workflow for both manual and automated platforms from both Leica Biosystems and Roche Tissue Diagnostics.
Customer Success Stories
UCSF School of Medicine
Webinar: Expand Your Spatial Multiomics
In this webinar you will learn more about a new service capability offered through our Professional Assay Services that enables true multiomic detection of both proteins and RNAs on the same section. This new service enables researchers to detect up to 12 protein or RNA targets in any combination.
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