Chk2 Products
The Chk2 checkpoint kinase is an integral member of the signaling cascade that controls cell cycle checkpoints. In response to genotoxic insults Chk2 is phosphorylated by ATM or ATM-related kinases. Phosphorylation of Chk2 T68 promotes the formation of Chk2 oligomers. Oligomerization is a critical event in the activation of the Chk2 kinase as it is required for phosphorylation of additional Chk2 residues that lead to full activation and signaling to downstream effectors.
79 results for "Chk2" in Products
79 results for "Chk2" in Products
Chk2 Products
The Chk2 checkpoint kinase is an integral member of the signaling cascade that controls cell cycle checkpoints. In response to genotoxic insults Chk2 is phosphorylated by ATM or ATM-related kinases. Phosphorylation of Chk2 T68 promotes the formation of Chk2 oligomers. Oligomerization is a critical event in the activation of the Chk2 kinase as it is required for phosphorylation of additional Chk2 residues that lead to full activation and signaling to downstream effectors.
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat, Canine |
| Details: | Mouse IgG1 Monoclonal Clone #OTI5C4 |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Western Blot: Chk2 Antibody (OTI5C4) [NBP1-47695]](https://resources.bio-techne.com/images/products/Chk2-Antibody-OTI5C4-Western-Blot-NBP1-47695-img0020.jpg "Western Blot: Chk2 Antibody (OTI5C4) [NBP1-47695]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #73C175.1.1 |
| Applications: | IHC, WB, ICC/IF, Flow |
![Western Blot: Chk2 Antibody (73C175.1.1) [NB100-56546]](https://resources.bio-techne.com/images/products/Chk2-Antibody-73C175-1-1-Western-Blot-NB100-56546-img0003.jpg "Western Blot: Chk2 Antibody (73C175.1.1) [NB100-56546]")
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #1238H |
| Applications: | WB, ICC |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #235303 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #4B7 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: Chk2 Antibody (4B7) [H00011200-M01]](https://resources.bio-techne.com/images/products/Chk2-Antibody-4B7-Western-Blot-H00011200-M01-img0011.jpg "Western Blot: Chk2 Antibody (4B7) [H00011200-M01]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL9440 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: Chk2 Antibody (CL9440) [NBP2-88933]](https://resources.bio-techne.com/images/products/Chk2-Antibody-CL9440-Western-Blot-NBP2-88933-img0008.jpg "Western Blot: Chk2 Antibody (CL9440) [NBP2-88933]")
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2521A |
| Applications: | WB |
| Source: | Sf 9 (baculovirus) |
| Accession #: | NM_007194 |
| Applications: | BA |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #8F12 |
| Applications: | WB, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: Chk2 Antibody (8F12) [NB100-500]](https://resources.bio-techne.com/images/products/Chk2-Antibody-8F12-Immunocytochemistry-Immunofluorescence-NB100-500-img0003.jpg "Immunocytochemistry/ Immunofluorescence: Chk2 Antibody (8F12) [NB100-500]")
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #1C12B8 |
| Applications: | ELISA, ICC/IF, IHC, WB |
| Assay Range: | 312 - 20,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: Chk2 Antibody [NBP1-90024]](https://resources.bio-techne.com/images/products/Chk2-Antibody-Western-Blot-NBP1-90024-img0007.jpg "Western Blot: Chk2 Antibody [NBP1-90024]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF, KO |
![Western Blot: Chk2 [p Thr68] Antibody [NBP3-13076]](https://resources.bio-techne.com/images/products/Chk2-[p-Thr68]-Antibody-Western-Blot-NBP3-13076-img0001.jpg "Western Blot: Chk2 [p Thr68] Antibody [NBP3-13076]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Chk2 [p Ser19] Antibody [NBP3-13328]](https://resources.bio-techne.com/images/products/Chk2-[p-Ser19]-Antibody-Western-Blot-NBP3-13328-img0001.jpg "Western Blot: Chk2 [p Ser19] Antibody [NBP3-13328]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Chk2 [p Ser516] AntibodyAzide and BSA Free [NBP3-16900]](https://resources.bio-techne.com/images/products/Chk2-[p-Ser516]-Antibody-Western-Blot-NBP3-16900-img0001.jpg "Western Blot: Chk2 [p Ser516] AntibodyAzide and BSA Free [NBP3-16900]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #JE43-12 |
| Applications: | WB |
![Chk2 [p Thr68] Antibody (JE43-12)](https://resources.bio-techne.com/images/products/nbp3-32756_rabbit-chk2-p-thr68-mab-je43-12-288202412442927.jpg "Western Blot: Chk2 [p Thr68] Antibody (JE43-12) [NBP3-32756]")
| Applications: | WB |
![Western Blot: Chk2 Overexpression Lysate [NBL1-09147]](https://resources.bio-techne.com/images/products/Chk2-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-09147-img0002.jpg "Western Blot: Chk2 Overexpression Lysate [NBL1-09147]")
| Applications: | WB |
![Western Blot: Chk2 Overexpression Lysate [NBP2-10753]](https://resources.bio-techne.com/images/products/Chk2-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-10753-img0001.jpg "Western Blot: Chk2 Overexpression Lysate [NBP2-10753]")
| Reactivity: | Human, Mouse, Rat, Canine |
| Details: | Mouse IgG1 Monoclonal Clone #OTI5C4 |
| Applications: | IHC, WB, ICC/IF, Flow, IP, +1 More |
| Applications: | AC |
| Applications: | AC |
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing
| Chemical Name: | 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
