Dihydrofolate Reductase Inhibitors: Small Molecules and Peptides
A member of the reductase family of enzymes, dihydrofolate reductase (DHFR) is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. DHFR plays a key role in cell growth and proliferation.
4 results for "Dihydrofolate Reductase Inhibitors Small Molecules and Peptides" in Products
4 results for "Dihydrofolate Reductase Inhibitors Small Molecules and Peptides" in Products
Dihydrofolate Reductase Inhibitors: Small Molecules and Peptides
A member of the reductase family of enzymes, dihydrofolate reductase (DHFR) is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. DHFR plays a key role in cell growth and proliferation.
Thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART
| Chemical Name: | N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid |
| Purity: | ≥98% |
Photoswitchable inhibitor of human dihydrofolate reductase
| Chemical Name: | N-[4-[(1E)-2-(2,4-Diamino-6-quinazolinyl)diazenyl]benzoyl]-L-glutamic acid |
| Purity: | ≥95% |
Cytotoxic agent
| Chemical Name: | N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid |
| Purity: | ≥99% (HPLC) |
Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor
| Chemical Name: | 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine |
| Purity: | ≥99% |
