p300 Products
The E1A-binding protein p300 is a histone acetyltransferase that also acts to acetylate other proteins, such as p53. p300 acts as a transcriptional coactivator that can serve as an adaptor molecule to bridge to transcriptional regulators. In addition, p300 binds to PCNA and may participate in chromatin remodeling.
The large p300 protein associates with CREB-binding protein(CBP) in numerous types of cells, forming the p300/CBP transcription co-activator that regulates gene expression by promoting acetylation of histones and other transcription factors, most notably p53. Dysregulation of the p300/CBP complex has been related to several types of human cancers.
96 results for "p300" in Products
96 results for "p300" in Products
p300 Products
The E1A-binding protein p300 is a histone acetyltransferase that also acts to acetylate other proteins, such as p53. p300 acts as a transcriptional coactivator that can serve as an adaptor molecule to bridge to transcriptional regulators. In addition, p300 binds to PCNA and may participate in chromatin remodeling.
The large p300 protein associates with CREB-binding protein(CBP) in numerous types of cells, forming the p300/CBP transcription co-activator that regulates gene expression by promoting acetylation of histones and other transcription factors, most notably p53. Dysregulation of the p300/CBP complex has been related to several types of human cancers.
| Reactivity: | Human, Mouse, Rat, Primate, Mustelid |
| Details: | Mouse IgG1 kappa Monoclonal Clone #RW105 |
| Applications: | WB, ICC/IF, Flow, IP, Func, +3 More |
![Immunocytochemistry/ Immunofluorescence: KAT3B/p300 Antibody (RW105) - BSA Free [NB100-616]](https://resources.bio-techne.com/images/products/KAT3B-p300-Antibody-RW105-Immunocytochemistry-Immunofluorescence-NB100-616-img0005.jpg "Immunocytochemistry/ Immunofluorescence: KAT3B/p300 Antibody (RW105) - BSA Free [NB100-616]")
| Reactivity: | Human, Mouse, Rat, Primate, Mustelid |
| Details: | Mouse IgG1 kappa Monoclonal Clone #RW128 |
| Applications: | WB, ICC/IF, Flow, IP |
![Immunocytochemistry/ Immunofluorescence: KAT3B/p300 Antibody (RW128) - BSA Free [NB100-507]](https://resources.bio-techne.com/images/products/KAT3B-p300-Antibody-RW128-Immunocytochemistry-Immunofluorescence-NB100-507-img0005.jpg "Immunocytochemistry/ Immunofluorescence: KAT3B/p300 Antibody (RW128) - BSA Free [NB100-507]")
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP, ChIP |
![Western Blot: KAT3B/p300 Antibody [NB500-161]](https://resources.bio-techne.com/images/products/KAT3B-p300-Antibody-Western-Blot-NB500-161-img0012.jpg "Western Blot: KAT3B/p300 Antibody [NB500-161]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, IHC, ChIP, ICC |
| Reactivity: | Human, Mouse, Rat, Primate, Mustelid |
| Details: | Mouse IgG1 kappa Monoclonal Clone #RW109 |
| Applications: | WB, ICC/IF, IP, ChIP |
![Western Blot: KAT3B/p300 Antibody (RW109) [NB100-617]](https://resources.bio-techne.com/images/products/KAT3B-p300-Antibody-RW109-Western-Blot-NB100-617-img0003.jpg "Western Blot: KAT3B/p300 Antibody (RW109) [NB100-617]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ELISA, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: KAT3B/p300 Antibody [NBP1-87693]](https://resources.bio-techne.com/images/products/KAT3B-p300-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-87693-img0004.jpg "Immunocytochemistry/ Immunofluorescence: KAT3B/p300 Antibody [NBP1-87693]")
| Applications: | WB, ELISA, MA, AP |
![SDS-PAGE: Recombinant Human KAT3B/p300 GST (N-Term) Protein [H00002033-Q01]](https://resources.bio-techne.com/images/products/Recombinant-Human-KAT3B-p300-Protein-SDS-Page-H00002033-Q01-img0002.jpg "SDS-PAGE: Recombinant Human KAT3B/p300 GST (N-Term) Protein [H00002033-Q01]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: KAT3B/p300 Antibody [NBP1-87694]](https://resources.bio-techne.com/images/products/KAT3B-p300-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-87694-img0006.jpg "Immunocytochemistry/ Immunofluorescence: KAT3B/p300 Antibody [NBP1-87694]")
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Applications: | ELISA |
| Applications: | AC |
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP, ChIP |
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP, ChIP |
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP, ChIP |
Potent and selective EP300 Degrader (PROTAC®)
| Chemical Name: | 12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)dodecanamide |
| Purity: | ≥98% (HPLC) |
Potent and selective p300/CBP inhibitor; orally bioavailable
| Chemical Name: | (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide |
| Purity: | ≥98% (HPLC) |
Potent p300/CBP inhibitor
| Chemical Name: | (1'S,3'R)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide |
| Purity: | ≥98% (HPLC) |
Potent CBP/p300 BRD inhibitor
| Chemical Name: | 2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole |
| Purity: | ≥98% (HPLC) |
Reversible and non-competitive CBP/p300 inhibitor
| Chemical Name: | 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione |
| Purity: | ≥98% (HPLC) |
High affinity and selective PCAF bromodomain inhibitor
| Chemical Name: | (1S, 2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Negative control for iP300w (Cat. No. 7270)
| Chemical Name: | (1'R,3'S)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat, Primate, Mustelid |
| Details: | Mouse IgG1 kappa Monoclonal Clone #RW105 |
| Applications: | WB, ICC/IF, Flow, IP, Func, +3 More |
| Reactivity: | Human, Mouse, Rat, Primate, Mustelid |
| Details: | Mouse IgG1 kappa Monoclonal Clone #RW128 |
| Applications: | WB, ICC/IF, Flow, IP |