Raf-1 Products
Raf-1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. The activated Raf-1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the Serine/Threonine specific protein kinases ERK1 and ERK2. Downstream of Raf-1, activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation, and cell migration.
26 results for "Raf-1" in Products
26 results for "Raf-1" in Products
Raf-1 Products
Raf-1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. The activated Raf-1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the Serine/Threonine specific protein kinases ERK1 and ERK2. Downstream of Raf-1, activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation, and cell migration.
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, Simple Western, IHC |
Potent, selective c-Raf1 kinase inhibitor
| Chemical Name: | 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one |
| Purity: | ≥98% (HPLC) |
| Source: | Sf 9 (baculovirus) |
| Accession #: | NM_002880 |
| Applications: | BA |
| Reactivity: | Bovine, Canine, Chicken, Primate |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: Raf-1 Antibody [H00005894-B01P]](https://resources.bio-techne.com/images/products/Raf-1-Antibody-Western-Blot-H00005894-B01P-img0004.jpg "Western Blot: Raf-1 Antibody [H00005894-B01P]")
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
| Chemical Name: | 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Bovine, Canine, Chicken, Primate |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Rat |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #1H4 |
| Applications: | WB, ELISA, Func, KD |
![Western Blot: Raf-1 Antibody (1H4) [H00005894-M03]](https://resources.bio-techne.com/images/products/Raf-1-Antibody-1H4-Western-Blot-H00005894-M03-img0007.jpg "Western Blot: Raf-1 Antibody (1H4) [H00005894-M03]")
Potent Raf kinase inhibitor
| Chemical Name: | 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #4G4 |
| Applications: | IHC, WB, ELISA, Flow, CyTOF-ready |
![Western Blot: Raf-1 Antibody (4G4)BSA Free [NBP2-37513]](https://resources.bio-techne.com/images/products/Raf-1-Antibody-4G4-Western-Blot-NBP2-37513-img0003.jpg "Western Blot: Raf-1 Antibody (4G4)BSA Free [NBP2-37513]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: Raf-1 Antibody [NBP1-85462]](https://resources.bio-techne.com/images/products/Raf-1-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-85462-img0006.jpg "Immunocytochemistry/ Immunofluorescence: Raf-1 Antibody [NBP1-85462]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR2181 |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #M208 |
| Applications: | WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR2183 |
| Applications: | WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR2182 |
| Applications: | WB |
Potent BRAF and CRAF inhibitor
| Chemical Name: | N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Purity: | ≥98% |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #S05-9B1 |
| Applications: | WB, ICC/IF |
![Western Blot: Raf-1 Antibody (S05-9B1) [NBP3-14880]](https://resources.bio-techne.com/images/products/Raf-1-Antibody-S05-9B1-Western-Blot-NBP3-14880-img0001.jpg "Western Blot: Raf-1 Antibody (S05-9B1) [NBP3-14880]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Raf-1 [p Ser471] Antibody](https://resources.bio-techne.com/images/products/nbp3-23359_rabbit-raf-1-p-ser471-pab-19920231915416.jpg "Western Blot: Raf-1 [p Ser471] Antibody [NBP3-23359] -")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Raf-1 [p Ser642] Antibody [NB300-306]](https://resources.bio-techne.com/images/products/Raf-1-[p-Ser642]-Antibody-Western-Blot-NB300-306-img0001.jpg "Western Blot: Raf-1 [p Ser642] Antibody [NB300-306]")
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Raf-1 [p Ser301] Antibody [NB300-305]](https://resources.bio-techne.com/images/products/Raf1-[p-Ser301]-Antibody-Western-Blot-NB300-305-img0001.jpg "Western Blot: Raf-1 [p Ser301] Antibody [NB300-305]")
| Applications: | AC |
| Applications: | WB |
![Western Blot: Raf-1 Overexpression Lysate [NBP2-08062]](https://resources.bio-techne.com/images/products/Raf1-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-08062-img0001.jpg "Western Blot: Raf-1 Overexpression Lysate [NBP2-08062]")
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
| Chemical Name: | 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine |
| Purity: | ≥98% |
| Applications: | ELISA |
