TIMP-3 Products
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
93 results for "TIMP-3" in Products
93 results for "TIMP-3" in Products
TIMP-3 Products
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Source: | NS0 |
Accession #: | P35625 |
Applications: | InhibAct |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #183551 |
Applications: | WB, IHC, IP |
Assay Range: | 62.5 - 4,000 pg/mL |
Applications: | ELISA |
Reactivity: | Human, Mouse, Rat, Canine, Bovine, +1 More |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, ICC/IF, Flow |
Contains 4 membranes-2 spotted in duplicate with antibodies against 35 different proteases and 2 spotted in duplicate with antibodies against 32 different protease inhibitors
Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Applications: | IP, CyTOF-reported, ICFlow |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Applications: | ICFlow |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB, IP |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Applications: | ICFlow |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Applications: | ICFlow |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Applications: | ICFlow |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Applications: | ICFlow |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Applications: | ICFlow |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Applications: | ICFlow |
Reactivity: | Human |
Details: | Mouse IgG2a Monoclonal Clone #277128 |
Applications: | ICFlow |
Applications: | ELISA, NULL |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB |
Contains 4 membranes - each spotted in duplicate with 32 different protease inhibitor antibodies
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IP |
Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #MM0036-7D3 |
Applications: | IHC, WB |
Recombinant Monoclonal Antibody
Reactivity: | Human, Rat |
Details: | Rabbit IgG Monoclonal Clone #PSH04-41 |
Applications: | WB, ICC/IF |
Reactivity: | Human, Porcine |
Details: | Mouse IgG2b Kappa Monoclonal Clone #C2 |
Applications: | IHC, WB, ICC/IF |