FKBP12 Products
FK506 binding protein, also called FKBP12 and FKBP1A, was originally characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues critical for proper folding of proteins. The macrolide immunosuppressants FK506 (Tacrolimus) and rapamycin bind to FKBP12 with high affinity, while the structurally related-compound cyclosporine binds with a much lower affinity. The binding of these drugs causes FKBP12 to become a potent inhibitor of calcineurin phosphatase activity and TOR kinase activity. Knockout mice lacking FKBP12 are morphologically normal, but develop cardiomyopathies that may be related to dysregulation of ryanodyne receptors.
150 results for "FKBP12" in Products
150 results for "FKBP12" in Products
FKBP12 Products
FK506 binding protein, also called FKBP12 and FKBP1A, was originally characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues critical for proper folding of proteins. The macrolide immunosuppressants FK506 (Tacrolimus) and rapamycin bind to FKBP12 with high affinity, while the structurally related-compound cyclosporine binds with a much lower affinity. The binding of these drugs causes FKBP12 to become a potent inhibitor of calcineurin phosphatase activity and TOR kinase activity. Knockout mice lacking FKBP12 are morphologically normal, but develop cardiomyopathies that may be related to dysregulation of ryanodyne receptors.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #422513 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1049713 |
| Applications: | WB, ICC |
| Source: | E. coli |
| Accession #: | NP_000792 |
| Applications: | InhibAct |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Western Blot: FKBP12 Antibody [NB300-508]](https://resources.bio-techne.com/images/products/FKBP12-Antibody-Western-Blot-NB300-508-img0009.jpg "Western Blot: FKBP12 Antibody [NB300-508]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #OTI3B3 |
| Applications: | IHC, WB, Flow |
![Western Blot: FKBP12 Antibody (OTI3B3) [NBP2-02093]](https://resources.bio-techne.com/images/products/FKBP12-Antibody-3B3-Western-Blot-NBP2-02093-img0002.jpg "Western Blot: FKBP12 Antibody (OTI3B3) [NBP2-02093]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: FKBP12 AntibodyBSA Free [NBP2-41272]](https://resources.bio-techne.com/images/products/FKBP12-Antibody-Western-Blot-NBP2-41272-img0001.jpg "Western Blot: FKBP12 AntibodyBSA Free [NBP2-41272]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #1E5-A12 |
| Applications: | WB, ELISA, Func |
![Western Blot: FKBP12 Antibody (1E5-A12) [H00002280-M01]](https://resources.bio-techne.com/images/products/FKBP12-Antibody-1E5-A12-Western-Blot-H00002280-M01-img0005.jpg "Western Blot: FKBP12 Antibody (1E5-A12) [H00002280-M01]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #9A2J5 |
| Applications: | WB |
![Western Blot: FKBP12 Antibody (9A2J5) [NBP3-15418]](https://resources.bio-techne.com/images/products/FKBP12-Antibody-9A2J5-Western-Blot-NBP3-15418-img0001.jpg "Western Blot: FKBP12 Antibody (9A2J5) [NBP3-15418]")
| Applications: | AC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: FKBP12 Antibody [NBP2-14017]](https://resources.bio-techne.com/images/products/FKBP12-Antibody-Western-Blot-NBP2-14017-img0003.jpg "Western Blot: FKBP12 Antibody [NBP2-14017]")
| Applications: | PAGE |
![SDS-PAGE: Recombinant Mouse FKBP12 His Protein [NBP2-52087]](https://resources.bio-techne.com/images/products/FKBP12-Recombinant-Protein-SDS-Page-NBP2-52087-img0001.jpg "SDS-PAGE: Recombinant Mouse FKBP12 His Protein [NBP2-52087]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA |
![Western Blot: FKBP12 Antibody [NBP2-99149]](https://resources.bio-techne.com/images/products/FKBP12-Antibody-Western-Blot-NBP2-99149-img0002.jpg "Western Blot: FKBP12 Antibody [NBP2-99149]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: FKBP12 Antibody [NBP2-97584]](https://resources.bio-techne.com/images/products/FKBP12-Antibody-Western-Blot-NBP2-97584-img0002.jpg "Western Blot: FKBP12 Antibody [NBP2-97584]")
| Reactivity: | Human, Porcine |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #E3 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
| Applications: | WB |
![Western Blot: FKBP12 Overexpression Lysate [NBL1-10732]](https://resources.bio-techne.com/images/products/FKBP12-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-10732-img0002.jpg "Western Blot: FKBP12 Overexpression Lysate [NBL1-10732]")
| Applications: | WB |
![Western Blot: FKBP12 Overexpression Lysate [NBL1-10733]](https://resources.bio-techne.com/images/products/FKBP12-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-10733-img0002.jpg "Western Blot: FKBP12 Overexpression Lysate [NBL1-10733]")
| Applications: | ELISA |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #OTI3B3 |
| Applications: | IHC, WB, Flow, CyTOF-ready |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #OTI3B3 |
| Applications: | IHC, WB, Flow, CyTOF-ready |